Public Review Draft July, 2014-Methylene Diphenyl Diisocyanate (MDI) Reference Exposure Levels (RELs)

Responses to Public Comment on the Draft Reference Exposure Levels for Methylene Diphenyl Diisocyanate Office of Environmental Health Hazard Assessment California Environmental Protection Agency

On July 4, 2014, the Office of Environmental Health Hazard Assessment (OEHHA) released the draft document, Methylene Diphenyl Diisocyanate Reference Exposure Levels: Technical Support Document for the Derivation of Noncancer Reference Exposure Levels to solicit public comment. Responses to comments received on the draft methylene diphenyl diisocyanate reference exposure levels (RELs) are provid...

DEVELOPMENT OF A PHYSIOLOGICALLY BASED TOXICOKINETIC MODEL FOR HUMAN EXPOSURE RISK ASSESSMENT OF METHYLENE DIPHENYL DIISOCYANATE(MDI)

Introduction: Given the lack of a developed physiologically based toxicokinetic (PBTK) model for human systemic exposure assessment of methylene diisocyanate (MDI) and prediction of its urinary metabolites, this study aims to develop a PBTK model for exposure risk assessment of MDI. Methods and Materials: In this study, to assess the potential exposure to the MDI, a PBTK model was constructed ...

Occupational asthma after exposure to plaster casts containing methylene diphenyl diisocyanate.

BACKGROUND The case of a 34-year-old female nurse is presented. She worked in an accident and emergency department in a district general hospital, with methylene diphenyl diisocyanate (MDI)-containing synthetic plaster casts. She worked with MDI on a daily basis for 4 years. She was out of the department for 1 year and on her return developed cough, wheeze and dyspnoea within 5 min of exposure ...

May 2015, Methylene Diphenyl Diisocyanate Reference Exposure Levels, SRP Review Dtaft II

Responses to Public Comment on the Draft Reference Exposure Levels for Toluene Diisocyanate Office of Environmental Health Hazard Assessment California Environmental Protection Agency

The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). OEHHA developed a Technical Support Document (TSD) in response to this statutory requirement that describes acute, 8 hour and chronic RELs and was adopted in December 2008. The T...